Enhanced Diode Array Detector Sensitivity and Automated Peak Purity Control

ثبت نشده
چکیده

The introduction of the diode array detector helped overcome this problem by providing access to quantitative as well as qualitative spectral information for a wide wavelength range. Agilent Technologie introduced the first diode array detector for liquid chromatography in 1982. Since that time significant improvements in the design of both the hardware and software have been made, Enhanced Diode Array Detector Sensitivity and Automated Peak Purity Control

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Peak purity analysis in HPLC and CE using diode-array technology Application

In terms of quality control and for all quantitative analysis peak purity is a major task, which can be addressed in different ways. Often only peak shapes and chromatograms are taken into consideration but a very elegant possibility without the need to use a mass spectrometric detector is the comparison of spectra recorded with a diode-array detector during the registration of a chromatographi...

متن کامل

Peak Purity Determination with a Diode Array Detector

Peak purity analysis is an evaluation technique for detecting the presence of coeluting impurities in highperformance liquid chromatography (HPLC) data. Running a peak purity check prior to analytical quantitation helps to ensure accuracy. In the development of analytical methods, peak purity analysis can reveal the presence of contamination during standardization and, by doing so, can prevent ...

متن کامل

Analysis of low-dose benzodiazepines by HPLC with automated solid-phase extraction.

We describe a simple, specific, and sensitive reversed-phase HPLC method with automated solid-phase extraction (SPE) for analyzing alprazolam, clonazepam, and nitrazepam concentrations in human serum or plasma. We prepare samples and calibrators with an automated sample preparer, using 100-mg Bond-Elut C18 SPE columns. The HPLC method uses isocratic elution with acetonitrile:methanol:dipotassiu...

متن کامل

Parallel Kalman filters for peak purity analysis: extensions to non-ideal detector response

A mathematical method for detecting spectral impurities in liquid chromatographic peaks measured with a diode array detector (LC-DAD) is described. The new method compensates for certain measurement non-idealities, minimizing the likelihood of a false indication of an impurity. The algorithm, evolving projection analysis, is based on a previously reported method in which points in an n-dimensio...

متن کامل

Purity Assessment of Drug Discovery Compound Libraries Using an Agilent Single Quadrupole LC/MS System Coupled to Diode Array and Evaporative Light Scattering Detectors

Medicinal and analytical scientists supporting pharmaceutical medicinal chemistry efforts usually assess the purity of synthesized compounds prior to selecting them for biological activity. This application note demonstrates a fast and automated purity assessment of a 30 compound library using one generic method and a multidetector system. The use of the Agilent 6130 Series Single Quadrupole LC...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 1999